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Article

Structural instability of plasmid biopharmaceuticals: challenges and implications.

Trends in biotechnology - 1 Sept 2009

Oliveira Pedro H, Prather Kristala Jones, Prazeres Duarte M F, Monteiro Gabriel A

Abstract excerpt

The global increase in the number of applications involving therapeutic plasmid DNA (pDNA) is creating a need for large amounts of highly stable and purified molecules. One of the main obstacles during the developmental stages of a new therapeutic DNA molecule involves tackling a wide array of structural instability events occurring in/with pDNA and therefore assuring its structural integrity. This review focuses...

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PMID: 19656584
DOI: 10.1016/j.tibtech.2009.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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