Article

Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost

2024-02-06

Abstract excerpt

<h4>ABSTRACT</h4> Plasmids play a major role in rapid adaptation of bacteria by facilitating horizontal transfer of diverse genes, most notably those conferring antibiotic resistance. While most plasmids that replicate in a broad range of bacteria also persist well in diverse hosts, there are exceptions that are poorly understood. We investigated why a broad-host range plasmid, pBP136, originally found in clinica...

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Literature Corpus work: 01a77fa5-f75c-5162-ad3c-612d1a12aa33
DOI: 10.1101/2024.02.05.579024

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