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Article

A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid Produces a Reversible Increase in Antibiotic Resistance.

Antimicrobial agents and chemotherapy - 1 Feb 2017

Santos-Lopez Alfonso, Bernabe-Balas Cristina, Ares-Arroyo Manuel, Ortega-Huedo Rafael, Hoefer Andreas, San Millan Alvaro, Gonzalez-Zorn Bruno

Abstract excerpt

ColE1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in Pasteurellaceae In this study, we describe how a natural single nucleotide polymorphism (SNP) near the origin of replication of the ColE1-type plasmid pB1000 found in a Pasteurella multocida clinical isolate generates two independent plasmid variants able to coexist in the same cell simultaneously....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27895020
DOI: 10.1128/AAC.01735-16
PMCID: PMC5278757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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