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Article

Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development.

Molecular systems biology - 1 Jan 2010

Onichtchouk Daria, Geier Florian, Polok Bozena, Messerschmidt Daniel M, Mössner Rebecca, Wendik Björn, Song Sungmin, Taylor Verdon, Timmer Jens, Driever Wolfgang

Abstract excerpt

The transcription factor POU5f1/OCT4 controls pluripotency in mammalian ES cells, but little is known about its functions in the early embryo. We used time-resolved transcriptome analysis of zebrafish pou5f1 MZspg mutant embryos to identify genes regulated by Pou5f1. Comparison to mammalian systems defines evolutionary conserved Pou5f1 targets. Time-series data reveal many Pou5f1 targets with delayed or advanced...

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Identifiers

PMID: 20212526
DOI: 10.1038/msb.2010.9
PMCID: PMC2858445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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