Article
Heart morphogenesis gene regulatory networks revealed by temporal expression analysis.
Development (Cambridge, England) - 1 Oct 2017
Hill Jonathon T, Demarest Bradley, Gorsi Bushra, Smith Megan, Yost H Joseph
Abstract excerpt
During embryogenesis the heart forms as a linear tube that then undergoes multiple simultaneous morphogenetic events to obtain its mature shape. To understand the gene regulatory networks (GRNs) driving this phase of heart development, during which many congenital heart disease malformations likely arise, we conducted an RNA-seq timecourse in zebrafish from 30 hpf to 72 hpf and identified 5861 genes with altered...
Topics
- Animals
- Cluster Analysis
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Gene Regulatory Networks
- Genes, Duplicate
- Heart
- Mice
- Morphogenesis
- Mutation
- Nucleotide Motifs