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Article

Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.

The international journal of neuropsychopharmacology - 1 Aug 2007

Mandelli Laura, Serretti Alessandro, Marino Elena, Pirovano Adele, Calati Raffaella, Colombo Cristina

Abstract excerpt

It is well established that stress is a risk factor for onset of mood disorders. Emerging evidence suggests that genetic vulnerability may also moderate individual responsiveness to stress. The most compelling evidence regards the polymorphism within the promoter region of the serotonin transporter gene (SERTPR), which has been reported to moderate the risk for depression, in conjunction with life stressors. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

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Share to Receptor, Serotonin, 5-HT1A

Share to Receptors, Dopamine D4

Share to Serotonin Plasma Membrane Transport Proteins

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Source

Identifiers

PMID: 16756688
DOI: 10.1017/S1461145706006882

Genes

COMT
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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