Article
New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype.
Biological psychiatry - 15 Sept 2008
Lazary Judit, Lazary Aron, Gonda Xenia, Benko Anita, Molnar Eszter, Juhasz Gabriella, Bagdy Gyorgy
Abstract excerpt
BACKGROUND: Since the first report of the significant gene-environment interaction (G x E) in depression published by Caspi et al., the literature is considerably contradictory in this field. To clarify this question, we analyzed the interaction between the serotonin transporter gene (SLC6A4) and threatening life events (TLE) on Zung Self-Rating Depression Score (ZSDS). METHODS: Five markers tagging the whole...
Topics
- Adult
- DNA Primers
- Depressive Disorder, Major
- Environment
- Female
- Haplotypes
- Humans
- Introns
- Life Change Events
- Male
- Phenotype