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Article

Fas/CD95 Deficiency in ApcMin/+ Mice Increases Intestinal Tumor Burden

4 Feb 2010

Abstract excerpt

BACKGROUND: Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L. Defects in the Fas-mediated apoptotic pathway have been reported in colorectal cancer. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, a variant of the Apc(Min/+) mouse, a model for the human condition, Familial Adenomatous Polyposis (FAP), was generated with an...

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PMID: 20140201
DOI: 10.1371/journal.pone.0009070

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Fas/CD95 Deficiency in ApcMin/+ Mice Increases Intestinal Tumor BurdenPMID 20140201Read ↗

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