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Article

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

28 Feb 2025

Abstract excerpt

Expression of interleukin (IL)-17 family cytokines is associated with tumor-promoting inflammation. We found that low expression of IL17RA associated with worse prognosis in late-stage colorectal cancer (CRC) patients. Deletion of Il17ra in intestinal epithelial cells (IECs) in a murine model of CRC enhanced epithelial-to-mesenchymal transition (EMT) via increased expression of the epidermal growth factor...

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PMID: 40023157
DOI: 10.1016/j.immuni.2025.02.005

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