Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.

doi:10.1186/ar2948

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Article

Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.

Arthritis research & therapy - 1 Jan 2010

Christensen Anne Friesgaard, Sørensen Grith Lykke, Hørslev-Petersen Kim, Holmskov Uffe, Lindegaard Hanne Merete, Junker Kirsten, Hetland Merete Lund, Stengaard-Pedersen Kristian, Jacobsen Søren, Lottenburger Tine, Ellingsen Torkell, Andersen Lis Smedegaard, Hansen Ib, Skjødt Henrik, Pedersen Jens Kristian, Lauridsen Ulrik Birk, Svendsen Anders, Tarp Ulrik, Pødenphant Jan, Vestergaard Aage, Jurik Anne Grethe, Østergaard Mikkel, Junker Peter

Abstract excerpt

INTRODUCTION: Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation...

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PMID: 20211020
DOI: 10.1186/ar2948
PMCID: PMC2888186

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