Article
Surfactant protein D multimerization and gene polymorphism in COPD and asthma.
Respirology (Carlton, Vic.) - 1 Mar 2018
Fakih Dalia, Akiki Zeina, Junker Kirsten, Medlej-Hashim Myrna, Waked Mirna, Salameh Pascale, Holmskov Uffe, Bouharoun-Tayoun Hasnaa, Chamat Soulaima, Sorensen Grith L, Jounblat Rania
Abstract excerpt
BACKGROUND AND OBJECTIVE: A structural single nucleotide polymorphism rs721917 in the surfactant protein D (SP-D) gene, known as Met11Thr, was reported to influence the circulating levels and degree of multimerization of SP-D and was associated with both COPD and atopy in asthma. Moreover, disease-related processes are known to degrade multimerized SP-D, however, the degree of the protein degradation in these...
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