Article
Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Scandinavian journal of immunology - 1 Jan 2008
Hoegh S V, Lindegaard H M, Sorensen G L, Høj A, Bendixen C, Junker P, Holmskov U
Abstract excerpt
Innate immune system abnormalities, e.g., mannan-binding lectin (MBL) genotype variants, have been demonstrated to modify the disease course of rheumatoid arthritis (RA). Surfactant protein D (SP-D) shares important structural and functional properties with MBL suggesting that SP-D may be an additional RA disease modifier. The Met11Thr polymorphism in the N-terminal part of SP-D is an important determinant for...
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