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Article

Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults.

Immunity, inflammation and disease - 1 Feb 2022

Hoffmann-Petersen Benjamin, Suffolk Raymond, Petersen Jens J H, Petersen Thomas H, Brasch-Andersen Charlotte, Høst Arne, Halken Susanne, Sorensen Grith L, Agertoft Lone

Abstract excerpt

BACKGROUND: Surfactant Protein D (SP-D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP-D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients suffering from asthma, possibly due to a combination of induced SP-D synthesis and decreased air-blood barrier...

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Identifiers

PMID: 34780682
DOI: 10.1002/iid3.560
PMCID: PMC8767520

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