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Article

A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2005

Leth-Larsen Rikke, Garred Peter, Jensenius Henriette, Meschi Joseph, Hartshorn Kevan, Madsen Jens, Tornoe Ida, Madsen Hans O, Sørensen Grith, Crouch Erika, Holmskov Uffe

Abstract excerpt

Surfactant protein D (SP-D) plays important roles in the host defense against infectious microorganisms and in regulating the innate immune response to a variety of pathogen-associated molecular pattern. SP-D is mainly expressed by type II cells of the lung, but SP-D is generally found on epithelial surfaces and in serum. Genotyping for three single-nucleotide variations altering amino acids in the mature protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15661913
DOI: 10.4049/jimmunol.174.3.1532

Genes

SFTPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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