Article
WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
PloS one - 2 Mar 2010
Chen Chang-Shi, Bellier Audrey, Kao Cheng-Yuan, Yang Ya-Luen, Chen Huan-Da, Los Ferdinand C O, Aroian Raffi V
Abstract excerpt
Pore-forming toxins (PFTs) are the single largest class of bacterial virulence factors. The DAF-2 insulin/insulin-like growth factor-1 signaling pathway, which regulates lifespan and stress resistance in Caenorhabditis elegans, is known to mutate to resistance to pathogenic bacteria. However, its role in responses against bacterial toxins and PFTs is as yet unexplored. Here we reveal that reduction of the DAF-2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.