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A <i>Caenorhabditis elegans nck-1</i> and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins

2022-06-10

Abstract excerpt

Pore-forming proteins (PFPs) comprise the largest single class of bacterial protein virulence factors and are expressed by many human and animal bacterial pathogens. Cells that are attacked by these virulence factors activate epithelial intrinsic cellular defenses (or INCEDs) to prevent the attendant cellular damage, cellular dysfunction, osmotic lysis, and organismal death. Several conserved PFP INCEDs have been...

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Literature Corpus work
ccfc5b0c-274e-53fc-b9d4-7710a96ab3b3
DOI
10.1101/2022.06.10.495598
Open publication

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