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Article

The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.

Aging cell - 1 Dec 2008

Evans Eric A, Chen Will C, Tan Man-Wah

Abstract excerpt

The Caenorhabditis elegans DAF-2 insulin-like signaling pathway, which regulates lifespan and stress resistance, has also been implicated in resistance to bacterial pathogens. Loss-of-function daf-2 and age-1 mutants have increased lifespans and are resistant to a variety of bacterial pathogens. This raises the possibility that the increased longevity and the pathogen resistance of insulin-like signaling pathway...

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Source

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Identifiers

PMID: 18782349
DOI: 10.1111/j.1474-9726.2008.00435.x
PMCID: PMC2630471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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