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Article

Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.

Developmental cell - 1 Jul 2008

Haskins Kylie A, Russell Jonathan F, Gaddis Nathan, Dressman Holly K, Aballay Alejandro

Abstract excerpt

The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense to pathogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18606143
DOI: 10.1016/j.devcel.2008.05.006
PMCID: PMC2517226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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