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Tris(1,3-dichloro-2-propyl)phosphate Reduces the Lifespan via Activation of an Unconventional Insulin/Insulin-Like Growth Factor-1 Signaling Pathway.

Environmental science & technology - 1 Sept 2020

Wang Chen, Chen Haibo, Li Hui, Zhang Yunchao, Ren Luyao, Chen Chao, Wang Xiaoli, Yu Jun, Li Zongrui, Liu Yongdi

Abstract excerpt

Tris(1,3-dichloro-2-propyl)phosphate (TDCPP) is an environmental contaminant that has attracted increasing concern due to its presence in environmental media and biological samples. Our previous study demonstrated that exposure to TDCPP reduced the lifespan of Caenorhabditis elegans, but the mechanisms, including the relevant signaling pathways, are unclear. The current study found that TDCPP exposure triggers an...

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PMID: 32786597
DOI: 10.1021/acs.est.0c03630

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