Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.

The Journal of biological chemistry - 15 Jan 2010

Alper Scott, McElwee Matthew K, Apfeld Javier, Lackford Brad, Freedman Jonathan H, Schwartz David A

Abstract excerpt

The relationship between the mechanisms that control an organism's lifespan and its ability to respond to environmental challenges are poorly understood. In Caenorhabditis elegans, an insulin-like signaling pathway modulates lifespan and the innate immune response to bacterial pathogens via a common mechanism involving transcriptional regulation by the DAF-16/FOXO transcription factor. The C. elegans germ line...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Forkhead Transcription Factors
Share to Germ Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucagon-Like Peptide 1

Share to Longevity

Share to Mitogen-Activated Protein Kinases

Share to p38 Mitogen-Activated Protein Kinases

Share to Pseudomonas aeruginosa

Share to Serratia marcescens

Source

Open in PubMed Open full text

Identifiers

PMID: 19923212
DOI: 10.1074/jbc.M109.057323
PMCID: PMC2804340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.PMID 19923212Read ↗

The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.Semantic proximity Read ↗

Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.Semantic proximity Read ↗

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.Semantic proximity Read ↗

GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Regulation of DAF-16-mediated longevity and immune response to Candida albicans infection in Caenorhabditis elegans.Semantic proximity Read ↗

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.Semantic proximity Read ↗

Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs.Semantic proximity Read ↗

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.Semantic proximity Read ↗

Signals from the reproductive system regulate the lifespan of C. elegans.Semantic proximity Read ↗

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of LifespanSemantic proximity Read ↗

Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.Semantic proximity Read ↗

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogasterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.