Article
Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2010
Blanchard Carine, Stucke Emily M, Burwinkel Karen, Caldwell Julie M, Collins Margaret H, Ahrens Annette, Buckmeier Bridget K, Jameson Sean C, Greenberg Allison, Kaul Ajay, Franciosi James P, Kushner Jonathan P, Martin Lisa J, Putnam Philip E, Abonia J Pablo, Wells Suzanne I, Rothenberg Marc E
Abstract excerpt
We have previously proposed that the pathogenesis of eosinophilic esophagitis (EE) is mediated by an IL-13-driven epithelial cell response associated with marked gene dysregulation including eotaxin-3 overproduction. In this study, we compared epithelial responses between healthy patients and those with EE, aiming to uncover molecular explanations for EE pathogenesis. Esophageal epithelial cells could be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.