Article

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils

2024-08-23

Abstract excerpt

<h4>Background: </h4> Eosinophilic esophagitis (EoE) is a chronic allergic disease characterized by esophageal dysfunction, type-2 inflammation, and esophageal eosinophilic infiltrate. While proton pump inhibitor (PPI) therapy is commonly used for EoE management, the underlying mechanism of action remains unclear. <h4>Methods:</h4> Air-liquid interface culture of esophageal epithelial cells was employed to investi...

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Literature Corpus work: 461e6f9b-5234-56fa-bfa5-82be1c90c13a
DOI: 10.1101/2024.08.22.609219

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