Article
Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis.
The Journal of allergy and clinical immunology - 1 Sept 2017
Rochman Mark, Travers Jared, Miracle Cora E, Bedard Mary C, Wen Ting, Azouz Nurit P, Caldwell Julie M, Kc Kiran, Sherrill Joseph D, Davis Benjamin P, Rymer Jeffrey K, Kaufman Kenneth M, Aronow Bruce J, Rothenberg Marc E
Abstract excerpt
BACKGROUND: A key question in the allergy field is to understand how tissue-specific disease is manifested. Eosinophilic esophagitis (EoE) is an emerging tissue-specific allergic disease with an unclear pathogenesis. OBJECTIVE: Herein we tested the hypothesis that a defect in tissue-specific esophageal genes is an integral part of EoE pathogenesis. METHODS: We interrogated the pattern of expression of...
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