Article
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.
The Journal of clinical investigation - 1 Feb 2006
Blanchard Carine, Wang Ning, Stringer Keith F, Mishra Anil, Fulkerson Patricia C, Abonia J Pablo, Jameson Sean C, Kirby Cassie, Konikoff Michael R, Collins Margaret H, Cohen Mitchell B, Akers Rachel, Hogan Simon P, Assa'ad Amal H, Putnam Philip E, Aronow Bruce J, Rothenberg Marc E
Abstract excerpt
Eosinophilic esophagitis (EE) is an emerging disorder with a poorly understood pathogenesis. In order to define disease mechanisms, we took an empirical approach analyzing esophageal tissue by a genome-wide microarray expression analysis. EE patients had a striking transcript signature involving 1% of the human genome that was remarkably conserved across sex, age, and allergic status and was distinct from that...
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