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Eosinophil specialization is regulated by exposure to the esophageal epithelial microenvironment

9 May 2024

Abstract excerpt

Distinct subsets of eosinophils are reported in inflammatory and healthy tissues, yet the functions of uniquely specialized eosinophils and the signals that elicit them, particularly in eosinophilic esophagitis, are not well understood. Herein, we report an ex vivo system wherein freshly isolated human eosinophils were cocultured with esophageal epithelial cells and disease-relevant proinflammatory (IL-13) or...

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PMID: 38723185
DOI: 10.1093/jleuko/qiae102

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