Article
Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer.
Molecular oncology - 1 Feb 2011
Rønneberg Jo Anders, Fleischer Thomas, Solvang Hiroko Kato, Nordgard Silje H, Edvardsen Hege, Potapenko Ivan, Nebdal Daniel, Daviaud Christian, Gut Ivo, Bukholm Ida, Naume Bjørn, Børresen-Dale Anne-Lise, Tost Jörg, Kristensen Vessela
Abstract excerpt
Breast cancer is a heterogeneous disease that can be divided in subtypes based on histology, gene expression profiles as well as differences in genomic aberrations. Distinct global DNA methylation profiles have been reported in normal breast epithelial cells as well as in breast tumors. However, the influence of the tumor methylome on the previously described subgroups of breast cancer is not fully understood....
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