Article
Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis.
Circulation research - 16 Apr 2010
Carramolino Laura, Fuentes Joana, García-Andrés Clara, Azcoitia Valeria, Riethmacher Dieter, Torres Miguel
Abstract excerpt
RATIONALE: Several mutations that impair the development of blood lineages in the mouse also impair the formation of the lymphatic vasculature and its separation from the blood vasculature. However, the basis for these defects has remained unknown because the mutations characterized affect more than one blood lineage. OBJECTIVE: We tested the hypothesis that megakaryocytes/platelets are required for the formation...
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