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Article

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.

The EMBO journal - 2 Apr 2002

Wigle Jeffrey T, Harvey Natasha, Detmar Michael, Lagutina Irina, Grosveld Gerard, Gunn Michael D, Jackson David G, Oliver Guillermo

Abstract excerpt

The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In Prox1(-)(/-) embryos, this budding becomes arrested at around embryonic day...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11927535
DOI: 10.1093/emboj/21.7.1505
PMCID: PMC125938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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