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Common features of megakaryocytes and hematopoietic stem cells: What's the connection?

2 Jun 2009

Abstract excerpt

Megakaryocytes (Mks) are rare polyploid bone marrow cells whose function is to produce blood platelets. Since the purification and cloning of the major Mk cytokine, thrombopoietin, in 1994, considerable progress has been made in understanding the biology of Mk development. Remarkably, these advances have revealed a number of key features of Mks that are shared with hematopoietic stem cells (HSCs), such as common...

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PMID: 19492306
DOI: 10.1002/jcb.22184

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