Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically determined phenotype covariation networks control bone strength.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2010

Jepsen Karl J, Courtland Hayden-William, Nadeau Joseph H

Abstract excerpt

To identify genes affecting bone strength, we studied how genetic variants regulate components of a phenotypic covariation network that was previously shown to accurately characterize the compensatory trait interactions involved in functional adaptation during growth. Quantitative trait loci (QTLs) regulating femoral robustness, morphologic compensation, and mineralization (tissue quality) were mapped at three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 20200957
DOI: 10.1002/jbmr.41
PMCID: PMC3154000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically determined phenotype covariation networks control bone strength.PMID 20200957Read ↗

Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains.Semantic proximity Read ↗

Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae.Semantic proximity Read ↗

Genetic variation in bone growth patterns defines adult mouse bone fragility.Semantic proximity Read ↗

Characterization of complex, co-adapted skeletal biomechanics phenotypes: a needed paradigm shift in the genetics of bone structure and function.Semantic proximity Read ↗

Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross.Semantic proximity Read ↗

Systems analysis of bone.Semantic proximity Read ↗

Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice.Semantic proximity Read ↗

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.Semantic proximity Read ↗

Mapping quantitative trait loci that influence femoral cross-sectional area in mice.Semantic proximity Read ↗

Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry.Semantic proximity Read ↗

Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults.Semantic proximity Read ↗

Linkage mapping of femoral material properties in a reciprocal intercross of HcB-8 and HcB-23 recombinant mouse strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.