Article
Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2009
Tommasini Steven M, Hu Bin, Nadeau Joseph H, Jepsen Karl J
Abstract excerpt
Conventional approaches to identifying quantitative trait loci (QTLs) regulating bone mass and fragility are limited because they examine cortical and trabecular traits independently. Prior work examining long bones from young adult mice and humans indicated that skeletal traits are functionally related and that compensatory interactions among morphological and compositional traits are critical for establishing...
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