Article
Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2006
Wergedal Jon E, Ackert-Bicknell Cheryl L, Tsaih Shirng-Wern, Sheng Matilda H-C, Li Renhua, Mohan Subburamen, Beamer Wesley G, Churchill Gary A, Baylink David J
Abstract excerpt
UNLABELLED: Genetic analysis of an NZB/B1NJ x RF/J cross has identified QTLs for femur mechanical, geometric, and densitometric phenotypes. Most mechanical QTLs were associated with geometric QTLs, strongly suggesting common genetic regulation. INTRODUCTION: Previous studies have shown that bone architecture and BMD are important factors affecting bone strength, and both are genetically regulated. We conducted...
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