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Article

Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2011

Jepsen Karl J, Centi Amanda, Duarte G Felipe, Galloway Kathleen, Goldman Haviva, Hampson Naomi, Lappe Joan M, Cullen Diane M, Greeves Julie, Izard Rachel, Nindl Bradley C, Kraemer William J, Negus Charles H, Evans Rachel K

Abstract excerpt

Having a better understanding of how complex systems like bone compensate for the natural variation in bone width to establish mechanical function will benefit efforts to identify traits contributing to fracture risk. Using a collection of pQCT images of the tibial diaphysis from 696 young adult women and men, we tested the hypothesis that bone cells cannot surmount the nonlinear relationship between bone width...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21898595
DOI: 10.1002/jbmr.497

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