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Article

Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma.

Genes, chromosomes & cancer - 1 Jun 2010

Mejia-Guerrero Salvador, Quejada Michael, Gokgoz Nalan, Gill Mona, Parkes Robert K, Wunder Jay S, Andrulis Irene L

Abstract excerpt

The chromosomal region 12q13-15 is recurrently amplified in osteosarcoma (OS), but its importance in bone tumor development remains unknown. Although there are two major candidate genes (MDM2, a TP53 downregulator, and CDK4, involved in cell cycle progression) considered to be the driving genes in this region, the size of the amplicon and number of genes involved have not been determined. In this study, we used...

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Source

Identifiers

PMID: 20196171
DOI: 10.1002/gcc.20761

Genes

MDM2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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