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Article

Analysis of SAS Gene and CDK4 and MDM2 Proteins in Low-Grade Osteosarcoma

1 Feb 1999

Abstract excerpt

The region q13-15 of chromosome 12 contains SAS, CDK4, and MDM2 genes that are rearranged or amplified in a variety of human sarcomas. This study evaluated SAS gene amplification, and MDM2 and CDK4 protein expression in 20 tumor samples of central low-grade osteosarcoma (16 primary, 3 recurrences, 1 lung metastasis). SAS amplification was analyzed by quantitative polymerase chain reaction (PCR), while from the...

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PMID: 10101594
DOI: 10.1046/j.1525-1500.1999.09907.x

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