Article
Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation.
Anticancer research - 1 Jan 2000
Kanoe H, Nakayama T, Murakami H, Hosaka T, Yamamoto H, Nakashima Y, Tsuboyama T, Nakamura T, Sasaki M S, Toguchida J
Abstract excerpt
Amplification of the CDK4 gene, which encodes a key molecule in the cell cycle, has been shown in some types of human neoplasms, including bone and soft tissue tumors. It is also reported that the CDK4 gene is coamplified with other sequences in the 12q13-15 region, including the MDM2 and SAS gen...
Topics
- Bone Neoplasms
- Cell Cycle
- Chondrosarcoma
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinases
- Gene Amplification
- Genes, Retinoblastoma
- Histiocytoma, Benign Fibrous
- Humans
- Lipoma
- Liposarcoma
- Membrane Proteins
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Osteosarcoma