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Article

Amplification of multiple regions of chromosome 12, including 12q13–15, in chronic lymphocytic leukaemia

1 Mar 1997

Abstract excerpt

Trisomy 12 is a frequent abnormality in chronic lymphocytic leukaemia (CLL). The biological importance of trisomy 12 is still poorly understood but it has been suggested that one or several genes are duplicated leading to malignant transformation. We present a case with amplification of 12q13-22 found in a clinically aggressive relapse of CLL. A smaller region, 12q13-15, was amplified most frequently and a YAC...

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PMID: 9150711
DOI: 10.1111/j.1600-0609.1997.tb00944.x

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