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Article

Amplification of CDK4 and MDM2 in malignant melanoma

17 Jan 2006

Abstract excerpt

Amplification of the 12q13-15 region is a common event in several human tumors including liposarcomas, gliomas, and osteosarcomas. We have demonstrated high-level amplification of 12q14 in a subset of uncultured malignant melanomas (3 of 53). High-resolution mapping of the amplicon using quantitative PCR revealed a bipartite amplicon consisting of a primary 50-kb amplicon centered on CDK4 and a secondary amplicon...

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Identifiers

PMID: 16419059
DOI: 10.1002/gcc.20310

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