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Article

MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas.

Oncotarget - 15 Nov 2016

Grünewald Inga, Trautmann Marcel, Busch Alina, Bauer Larissa, Huss Sebastian, Schweinshaupt Petra, Vollbrecht Claudia, Odenthal Margarete, Quaas Alexander, Büttner Reinhard, Meyer Moritz F, Beutner Dirk, Hüttenbrink Karl-Bernd, Wardelmann Eva, Stenner Markus, Hartmann Wolfgang

Abstract excerpt

Salivary duct carcinoma (SDC) is an aggressive adenocarcinoma of the salivary glands associated with poor clinical outcome. SDCs are known to carry TP53 mutations in about 50%, however, only little is known about alternative pathogenic mechanisms within the p53 regulatory network. Particularly, data on alterations of the oncogenes MDM2 and CDK4 located in the chromosomal region 12q13-15 are limited in SDC, while...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 27662657
DOI: 10.18632/oncotarget.12127
PMCID: PMC5342738

Genes

MDM2
CDK4
HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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