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MDM2 Amplified Sarcomas: A Literature Review

11 Mar 2021

Abstract excerpt

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer...

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PMID: 33799733
DOI: 10.3390/diagnostics11030496

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