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Cell Cycle Regulator Gene <i>CDC5L</i> , a Potential Target for 6p12-p21 Amplicon in Osteosarcoma

1 Jun 2008

Abstract excerpt

Osteosarcoma is a primary malignant tumor of bone arising from primitive bone-forming mesenchymal cells and accounts for approximately 60% of malignant bone tumors. Our comparative genomic hybridization (CGH) studies have identified frequent amplification at 6p12-p21, 12q13-q15, and 17p11.2 in osteosarcoma. Of these amplified regions, 6p12-p21 is particularly interesting because of its association with...

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PMID: 18567798
DOI: 10.1158/1541-7786.mcr-07-2115

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