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Article

Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.

The pharmacogenomics journal - 1 Dec 2010

Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook V J, Fitzgerald J M, Elwood K, Marra F, Brooks-Wilson A

Abstract excerpt

Treatment of latent tuberculosis infection (LTBI) generally includes isoniazid (INH), a drug that can cause serious hepatotoxicity. Carboxylesterases (CES) are important in the metabolism of a variety of substrates, including xenobiotics. We hypothesized that genetic variation in CES genes expressed in the liver could affect INH-induced hepatotoxicity. Three CES genes are known to be expressed in human liver:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20195289
DOI: 10.1038/tpj.2010.5

Genes

CES1
CES2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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