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Article

Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population.

Pharmacogenomics - 1 Sept 2009

Yamada So, Tang Mila, Richardson Kathryn, Halaschek-Wiener Julius, Chan Matthew, Cook Victoria J, Fitzgerald J Mark, Elwood R Kevin, Brooks-Wilson Angela, Marra Fawziah

Abstract excerpt

AIMS: TB is a serious global public health problem. Isoniazid, a key drug used to treat latent TB, can cause hepatotoxicity in some patients. This pilot study investigated the effects of genetic variation in NAT2 and CYP2E1 on isoniazid-induced hepatotoxicity in TB contacts in British Columbia, Canada. MATERIALS & METHODS: DNA re-sequencing was used to establish the spectrum of genetic variation in the exons,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19761367
DOI: 10.2217/pgs.09.66

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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