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Article

Relationship between CES2 genetic variations and rifampicin metabolism.

The Journal of antimicrobial chemotherapy - 1 Jun 2013

Song Sang Hoon, Chang Ho Eun, Jun Sun Hee, Park Kyoung Un, Lee Jae Ho, Lee Eun-Mi, Song Young-Han, Song Junghan

Abstract excerpt

OBJECTIVES: Rifampicin is known to be deacetylated in vivo, resulting in its metabolite 25-desacetyl rifampicin, but the enzyme metabolizing rifampicin and the association of this process with any genetic variation have not yet been elucidated. In this study, genetic variations of a surrogate enzyme, carboxylesterase 2 (CES2), and their association with the metabolism of this drug, were investigated. METHODS:...

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Identifiers

PMID: 23471941
DOI: 10.1093/jac/dkt036

Genes

CES2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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