Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.

Genetics - 1 May 2010

Calonge Teresa M, Eshaghi Majid, Liu Jianhua, Ronai Ze'ev, O'Connell Matthew J

Abstract excerpt

The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cdc25 by the Chk1 effector kinase. Upregulation of Chk1 by mutation or overexpression bypasses the requirement for upstream regulators or DNA damage to promote a G2 cell cycle arrest. We screened...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 1
Share to G2 Phase
Share to Histone Deacetylase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxamic Acids

Share to Mitosis

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20194963
DOI: 10.1534/genetics.110.114769
PMCID: PMC2870978

Genes

TRRAP
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20194963-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.PMID 20194963Read ↗

A tti1 mutation in the Tel2-Tti1-Tti2 complex specifically eliminates the cellular function of Rad3ATR, but not that of other PIKKs in fission yeast.Semantic proximity Read ↗

RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation.Semantic proximity Read ↗

TORC2 is required to maintain genome stability during S phase in fission yeast.Semantic proximity Read ↗

TRAIP regulates DNA double-strand break-induced ATM activationSemantic proximity Read ↗

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase ActivitiesSemantic proximity Read ↗

A novel chk1-dependent G1/M checkpoint in fission yeast.Semantic proximity Read ↗

<i>Drosophila</i> ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenanceSemantic proximity Read ↗

Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated.Semantic proximity Read ↗

Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.Semantic proximity Read ↗

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.Semantic proximity Read ↗

Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1.Semantic proximity Read ↗

Activation of a DNA damage checkpoint response in a TAF1-defective cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.