Article
Activation of a DNA damage checkpoint response in a TAF1-defective cell line.
Molecular and cellular biology - 1 Jun 2004
Buchmann Ann M, Skaar Jeffrey R, DeCaprio James A
Abstract excerpt
Although the link between transcription and DNA repair is well established, defects in the core transcriptional complex itself have not been shown to elicit a DNA damage response. Here we show that a cell line with a temperature-sensitive defect in TBP-associated factor 1 (TAF1), a component of the TFIID general transcription complex, exhibits hallmarks of an ATR-mediated DNA damage response. Upon inactivation of...
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