Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

31 Dec 2015

Abstract excerpt

ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and apoptosis, when...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26748709
DOI: 10.1016/j.celrep.2015.12.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase ActivitiesPMID 26748709Read ↗

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and RadiotherapySemantic proximity Read ↗

Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasisSemantic proximity Read ↗

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stressSemantic proximity Read ↗

Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell deathSemantic proximity Read ↗

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replicationSemantic proximity Read ↗

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11Semantic proximity Read ↗

Regulation and roles of Cdc7 kinase under replication stressSemantic proximity Read ↗

High levels of DNA replication initiation factors indicate ATRi sensitivity via excessive origin firingSemantic proximity Read ↗

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1Semantic proximity Read ↗

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferationSemantic proximity Read ↗

Targeting the ATR-CHK1 Axis in Cancer TherapySemantic proximity Read ↗

Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.