Article
Identification and characterization of the Drosophila tau homolog.
Mechanisms of development - 1 Oct 2001
Heidary G, Fortini M E
Abstract excerpt
A pathological hallmark of neurodegenerative tauopathies, including Alzheimer's disease and a group of clinically heterogeneous frontotemporal dementias, is the presence of intracellular neurofibrillary protein lesions (reviewed in Spillantini and Goedert, TINS 10 (1998) 428). The principal component of these structures is the microtubule-associated protein tau. Although tau is normally a highly soluble protein...
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