Article
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.
Human molecular genetics - 1 Mar 2007
Blard Olivier, Feuillette Sébastien, Bou Jacqueline, Chaumette Boris, Frébourg Thierry, Campion Dominique, Lecourtois Magalie
Abstract excerpt
Tauopathies, including Alzheimer's disease and fronto-temporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of aberrantly phosphorylated-tau. Tau is a neuronal microtubule-associated protein involved in microtubule assembly and stabilization. Currently, the molecular mechanisms...
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