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Article

Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice.

Synapse (New York, N.Y.) - 1 Jul 2010

Pfaffly Jennifer, Michaelides Michael, Wang Gene-Jack, Pessin Jeffrey E, Volkow Nora D, Thanos Panayotis K

Abstract excerpt

Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in rewar...

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Identifiers

PMID: 20175225
DOI: 10.1002/syn.20755
PMCID: PMC2873172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20175225-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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